#48: Had Native Americans Been Resistant to Old World Diseases How Different Would the New World Have Been?

Smallpox is arguably the deadliest weapon in history. Ninety percent of some Native American tribes were wiped out by this disease when they first encountered Western explorers.

But what if they hadn’t been wiped out? Would Native American groups have been able to successfully repel Western powers and keep North America for themselves? Or would colonial history largely have played out the same?

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